Halperin E C, Greenberg M S, Suit H D
Cancer. 1984 Jan 15;53(2):232-6. doi: 10.1002/1097-0142(19840115)53:2<232::aid-cncr2820530208>3.0.co;2-f.
Intensive chemotherapy and radiotherapy of Hodgkin's Disease has resulted in improved survival rates. With long-term follow-up, however, a risk of secondary malignancy in these individuals is now appreciated. The authors of this report have encountered five patients who developed bone or soft tissue sarcomata more than 5 years after treatment of Hodgkin's Disease. The four males and one female ranged in age from 14 to 74 years at the time of diagnosis of Hodgkin's disease. Two had received radiotherapy alone for treatment of Hodgkin's disease, two were treated with radiation and chemotherapy, and one received only chemotherapy. The latent period prior to diagnosis of sarcoma ranged from 6 to 11 years. There was one case each of neurofibrosarcoma, fibrosarcoma, osteosarcoma, liposarcoma and leiomyosarcoma. Four patients died within 1 year of the diagnosis of sarcoma. One is alive with no evidence of disease 2 years following diagnosis and surgical excision of the sarcoma. On the basis of the Massachusetts General Hospital experience in the treatment of Hodgkin's Disease, the authors calculate a risk of 0.9% of sarcoma occurring in five year survivors of Hodgkin's disease. Previously reported cases of sarcoma following treatment of Hodgkin's disease are summarized. The pertinent literature is reviewed.
霍奇金淋巴瘤的强化化疗和放疗提高了生存率。然而，随着长期随访，现在认识到这些患者存在继发恶性肿瘤的风险。本报告的作者遇到了5例在霍奇金淋巴瘤治疗5年多后发生骨或软组织肉瘤的患者。诊断霍奇金淋巴瘤时，这4名男性和1名女性的年龄在14岁至74岁之间。2例仅接受放疗治疗霍奇金淋巴瘤，2例接受放疗和化疗，1例仅接受化疗。肉瘤诊断前的潜伏期为6至ll年。分别有1例神经纤维肉瘤、纤维肉瘤、骨肉瘤、脂肪肉瘤和平滑肌肉瘤。4例患者在肉瘤诊断后1年内死亡。1例患者在肉瘤诊断并手术切除后2年存活，无疾病证据。根据麻省总医院治疗霍奇金淋巴瘤的经验，作者计算出霍奇金淋巴瘤5年幸存者发生肉瘤的风险为0.9%。总结了先前报道的霍奇金淋巴瘤治疗后发生肉瘤的病例。对相关文献进行了综述。
