Finer N N, Peters K L, Schindler R F, Grant G D
Ciba Found Symp. 1983;101:147-64.
In an attempt to determine the role of vitamin E in retrolental fibroplasia (RLF) we report our experience with 191 infants of less than 1500 g birth weight. Of these infants, 16.75% had evidence of acute RLF in hospital, 8.4% had cicatricial RLF at follow-up, and four infants (2.1%) were blind, none of whom had received supplementary vitamin E. The incidence of cicatricial RLF at follow-up was significantly lower in infants who received vitamin E early after birth (12 h) than in those who did not (3 of 105 versus 13 of 86, X2 = 9.26, P = 0.002), as was the incidence of Grade III or greater cicatrix (0 of 105 versus 7 of 86, X2 with Yates = 6.72, P = 0.01). Stepwise multiple linear regression analysis revealed three factors distinguishing infants who developed cicatricial RLF from those who did not: the lack of early vitamin E supplements (P = 0.0023), the significantly larger number of arterial PO2 values over 100 mmHg (P = 0.0056), and the presence of an intraventricular haemorrhage (P = 0.0032). The incidence and severity of necrotizing enterocolitis was similar in infants who received vitamin E and in those who did not. It is recommended that vitamin E be given within the first 12 hours of birth to all infants of less than 1500 g who require supplementary oxygen.
为了确定维生素E在晶状体后纤维增生症（RLF）中的作用，我们报告了对191例出生体重低于1500克的婴儿的研究经验。在这些婴儿中，16.75%在住院时有急性RLF的证据，8.4%在随访时有瘢痕性RLF，4名婴儿（2.1%）失明，他们均未接受过维生素E补充剂。出生后早期（12小时内）接受维生素E的婴儿随访时瘢痕性RLF的发生率显著低于未接受的婴儿（105例中有3例，而86例中有13例，X2 = 9.26，P = 0.002），III级或更严重瘢痕的发生率也是如此（105例中有0例，而86例中有7例，Yates校正X2 = 6.72，P = 0.01）。逐步多元线性回归分析显示，有三个因素可区分发生瘢痕性RLF的婴儿和未发生的婴儿：缺乏早期维生素E补充剂（P = 0.0023）、动脉血氧分压值超过100 mmHg的数量显著更多（P = 0.0056）以及存在脑室内出血（P = 0.0032）。接受维生素E和未接受维生素E的婴儿坏死性小肠结肠炎的发生率和严重程度相似。建议对所有需要补充氧气的出生体重低于1500克的婴儿在出生后的前12小时内给予维生素E。
