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恶性疟原虫的菌株特异性S抗原包含一个由11个氨基酸组成的重复序列。

Isolate-specific S-antigen of Plasmodium falciparum contains a repeated sequence of eleven amino acids.

作者信息

Coppel R L, Cowman A F, Lingelbach K R, Brown G V, Saint R B, Kemp D J, Anders R F

出版信息

Nature. 1983;306(5945):751-6. doi: 10.1038/306751a0.

DOI:10.1038/306751a0
PMID:6361573
Abstract

Antibodies raised against a Plasmodium falciparum protein expressed in Escherichia coli reacted with a 220,000-molecular weight antigen of mature blood-stage parasites. The protein resembles the sporozoite surface antigen being composed of tandem repeats of 11 amino acids. However, it is isolate-specific and the encoding gene is not detectable in strains that do not express the protein.

摘要

针对在大肠杆菌中表达的恶性疟原虫蛋白产生的抗体,与成熟血液阶段寄生虫的一种分子量为220,000的抗原发生反应。该蛋白类似于子孢子表面抗原,由11个氨基酸的串联重复序列组成。然而,它具有分离株特异性,并且在不表达该蛋白的菌株中无法检测到编码基因。

相似文献

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Isolate-specific S-antigen of Plasmodium falciparum contains a repeated sequence of eleven amino acids.恶性疟原虫的菌株特异性S抗原包含一个由11个氨基酸组成的重复序列。
Nature. 1983;306(5945):751-6. doi: 10.1038/306751a0.
2
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