Coppel R L, Cowman A F, Lingelbach K R, Brown G V, Saint R B, Kemp D J, Anders R F
Nature. 1983;306(5945):751-6. doi: 10.1038/306751a0.
Antibodies raised against a Plasmodium falciparum protein expressed in Escherichia coli reacted with a 220,000-molecular weight antigen of mature blood-stage parasites. The protein resembles the sporozoite surface antigen being composed of tandem repeats of 11 amino acids. However, it is isolate-specific and the encoding gene is not detectable in strains that do not express the protein.
针对在大肠杆菌中表达的恶性疟原虫蛋白产生的抗体,与成熟血液阶段寄生虫的一种分子量为220,000的抗原发生反应。该蛋白类似于子孢子表面抗原,由11个氨基酸的串联重复序列组成。然而,它具有分离株特异性,并且在不表达该蛋白的菌株中无法检测到编码基因。