恶性疟原虫裂殖子主要表面抗原前体的多态性：基因水平研究
Polymorphism of the precursor for the major surface antigens of Plasmodium falciparum merozoites: studies at the genetic level.
作者信息
Mackay M, Goman M, Bone N, Hyde J E, Scaife J, Certa U, Stunnenberg H, Bujard H
出版信息
EMBO J. 1985 Dec 30;4(13B):3823-9. doi: 10.1002/j.1460-2075.1985.tb04154.x.
Abstract
The gene for the precursor of Plasmodium falciparum merozoite surface antigens has been cloned. The entire sequence of the gene from a Thai isolate of the parasite is reported. It provides evidence for a signal peptide, a region containing short repeating peptides and an anchor sequence. In addition, the 5' end of a Papua New Guinea isolate has been sequenced. Comparison of these and other sequences defines, at the genetic level, a polymorphic region in the protein, and suggests that other parts of the protein are less susceptible to variation. Furthermore it appears that several signal peptides of P. falciparum exhibit extensive sequence homologies.
摘要
恶性疟原虫裂殖子表面抗原前体的基因已被克隆。报道了来自该寄生虫泰国分离株的该基因的完整序列。它为信号肽、包含短重复肽的区域和锚定序列提供了证据。此外，已对巴布亚新几内亚分离株的5'端进行了测序。这些序列与其他序列的比较在基因水平上定义了该蛋白质中的一个多态性区域，并表明该蛋白质的其他部分不易发生变异。此外，似乎恶性疟原虫的几种信号肽表现出广泛的序列同源性。
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