粪便中大肠杆菌的耐药性及抗菌药物在医院患者治疗中的应用。
Resistance of Escherichia coli in faeces and the use of antimicrobial agents in the treatment of hospital patients.
作者信息
Degener J E, Smit A C, Michel M F, Valkenburg H A, Muller L
出版信息
J Hyg (Lond). 1983 Dec;91(3):491-8. doi: 10.1017/s0022172400060538.
Resistance of faecal Escherichia coli to ampicillin, tetracycline, sulphamethoxazole and gentamicin was studied in patients admitted to seven different departments in two hospitals. The resistance of ampicillin, tetracycline and sulphamethoxazole in the seven patient groups was 27-57%, 26-56% and 35-63%, respectively. Resistance to gentamicin was found in only one department. An E. coli flora predominantly resistant to ampicillin, tetracycline or sulphamethoxazole (greater than 50% of the E. coli strains in a faecal sample resistant) was found in 10-38%, 4-30% and 21-35% of the samples. A cross-sectional study focusing on the influence of the use of antimicrobial agents on the occurrence of resistant strains revealed a positive correlation between the annual turnover of broad-spectrum penicillins in various departments and the occurrence of predominantly ampicillin-resistant E. coli strains in these departments.
在两家医院七个不同科室收治的患者中，对粪便中大肠杆菌对氨苄西林、四环素、磺胺甲恶唑和庆大霉素的耐药性进行了研究。七个患者组中氨苄西林、四环素和磺胺甲恶唑的耐药率分别为27% - 57%、26% - 56%和35% - 63%。仅在一个科室发现了对庆大霉素的耐药情况。在10% - 38%、4% - 30%和21% - 35%的样本中，发现大肠杆菌菌群主要对氨苄西林、四环素或磺胺甲恶唑耐药（粪便样本中超过50%的大肠杆菌菌株耐药）。一项关注抗菌药物使用对耐药菌株出现影响的横断面研究显示，各科室广谱青霉素的年使用量与这些科室主要对氨苄西林耐药的大肠杆菌菌株的出现之间存在正相关。
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