构巢曲霉hisB位点的双功能性和极化不忠性

Bifunctionality and polarized infidelity at the hisB locus of Aspergillus nidulans.

作者信息

Millington Ward A M, Reuser J A, Scheele J Y, van Lohuizen E J, van Gorkum van Diepen I R, Klasen E A, Bresser M

出版信息

Mol Gen Genet. 1984;193(2):332-9. doi: 10.1007/BF00330690.

Abstract

The histidine (hisB) locus of Aspergillus nidulans is unusual in two ways. Firstly, it is bifunctional; besides coding for imidazole glycerol phosphate (IGP) dehydrase, it is required for the production of ascospores (fertility). It appears, therefore, to be partly homologous to the hisB locus of Salmonella typhimurium, which codes for IGP dehydrase and histidinol phosphate phosphatase. Secondly, during meiosis it is often inaccurately transmitted to the progeny (infidelity). This phenomenon may be akin to the aberrant recombination events which cause Bar reversion in Drosophila, "selfing" in Salmonella and Neurospora, and gene fusions of the haemoglobin lepore type. A molecular model is proposed to account for the results.

摘要

构巢曲霉的组氨酸（hisB）基因座在两个方面与众不同。首先，它具有双功能；除了编码咪唑甘油磷酸（IGP）脱水酶外，它对于子囊孢子的产生（育性）也是必需的。因此，它似乎与鼠伤寒沙门氏菌的hisB基因座部分同源，后者编码IGP脱水酶和组氨醇磷酸磷酸酶。其次，在减数分裂过程中，它常常不准确地传递给后代（不忠现象）。这种现象可能类似于导致果蝇中棒眼回复、沙门氏菌和粗糙脉孢菌中“自交”以及血红蛋白 Lepore 型基因融合的异常重组事件。本文提出了一个分子模型来解释这些结果。