性别减缓了同宗配合型真菌构巢曲霉中有害突变的积累。
Sex slows down the accumulation of deleterious mutations in the homothallic fungus Aspergillus nidulans.
作者信息
Bruggeman Judith, Debets Alfons J M, Wijngaarden Pieter J, deVisser J Arjan G M, Hoekstra Rolf F
机构信息
Laboratory of Genetics, Department of Plant Sciences, Wageningen University, The Netherlands.
出版信息
Genetics. 2003 Jun;164(2):479-85. doi: 10.1093/genetics/164.2.479.
Coexistence of sexual and asexual reproduction within the same individual is an intriguing problem, especially when it concerns homothallic haplonts, like the fungus Aspergillus nidulans. In this fungus asexual and sexual offspring have largely identical genotypes. This genetic model organism is an ideal tool to measure possible fitness effects of sex (compared to asex) resulting from causes other than recombination. In this article we show that slightly deleterious mutations accumulate at a lower rate in the sexual pathway than in the asexual pathway. This secondary sex advantage may contribute to the persistence of sexual spores in this fungus. We propose that this advantage results from intra-organismal selection of the fittest gametes or zygotes, which is more stringent in the costly sexual pathway.
在同一个体中同时存在有性生殖和无性生殖是一个有趣的问题，尤其是当涉及到同宗配合的单倍体生物时，比如真菌构巢曲霉。在这种真菌中，无性生殖和有性生殖产生的后代基因型基本相同。这种遗传模式生物是衡量除重组之外的其他原因导致的有性生殖（与无性生殖相比）可能产生的适合度效应的理想工具。在本文中，我们表明，与无性生殖途径相比，轻微有害的突变在有性生殖途径中的积累速度更低。这种次生的有性生殖优势可能有助于这种真菌中孢子的持续存在。我们认为，这种优势源于对最适合的配子或合子的体内选择，这在成本较高的有性生殖途径中更为严格。
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