Toonen P A, Crommelin D J
Pharm Weekbl Sci. 1983 Dec 16;5(6):269-80. doi: 10.1007/BF02074854.
Recent literature dealing with the immunoglobulin-liposome combination as a tool for drug targeting is reviewed. Mechanisms for binding of immunoglobulins to liposomes are discussed. Results obtained so far by using this concept both to induce specific liposome-cell interactions in in vitro cell cultures and to target drug containing liposomes to selected tissues in animal studies are evaluated.
综述了近期有关将免疫球蛋白-脂质体组合作为药物靶向工具的文献。讨论了免疫球蛋白与脂质体结合的机制。评估了迄今为止通过使用这一概念在体外细胞培养中诱导特异性脂质体-细胞相互作用以及在动物研究中将含药脂质体靶向至选定组织所获得的结果。