Schäfer-Korting M, Korting H C, Braun-Falco O
Pharmakologisches Institut für Naturwissenschaftler, Johann Wolfgang-Goethe Universität, Frankfurt, West Germany.
J Am Acad Dermatol. 1989 Dec;21(6):1271-5. doi: 10.1016/s0190-9622(89)70342-x.
The production of liposomes, which was described in 1961, soon was claimed to be a useful technology for drug encapsulation. The first preparation (containing a topical antifungal agent), however, was registered only recently. Additional preparations, including some for topical therapy of skin disease, are under clinical investigation. Moreover, a variety of cosmetic products that contain liposomes is available today. In this article we review the literature on liposomes as it pertains to dermatology, including the basic principles of liposome structures and preparations, pharmacokinetics of liposomes and liposome-encapsulated drugs, and the influence on drug activity. Moreover, future applications of liposome preparations are discussed.
脂质体的制备于1961年被描述，很快就被认为是一种用于药物包封的有用技术。然而，第一种制剂（含有一种局部抗真菌剂）直到最近才注册。包括一些用于皮肤病局部治疗的其他制剂正在进行临床研究。此外，如今有多种含有脂质体的化妆品可供使用。在本文中，我们综述了与皮肤病学相关的脂质体文献，包括脂质体结构和制备的基本原理、脂质体及脂质体包封药物的药代动力学，以及对药物活性的影响。此外，还讨论了脂质体制剂的未来应用。
