Trubetskoĭ V S, Berdichevskiĭ V R, Efremov E E, Torchilin V P, Smirnov V N
Biull Eksp Biol Med. 1986 Sep;102(9):305-7.
A new approach to the targeted drug delivery is described. Unlike previous methods, associated with the necessity of specific immunoglobulin immobilization on the surface of drug-containing microcontainer, the present approach permits targeted transport of standardized container to a set of target antigens, using intermediate molecules-mediators possessing high and specific affinity to both vector antibody and standardized container. It was shown that simultaneous targeting of 14C-labeled liposomes to three target antigens using avidin-biotin system permits the increase in liposome binding to target monolayer by 30-50%, as compared to targeting of the same amount of liposomes to one antigen. The method developed is particularly promising in cases when relative availability of target antigens in the target organ is unknown.
本文描述了一种靶向药物递送的新方法。与以往需要在含药微容器表面固定特定免疫球蛋白的方法不同，本方法利用对载体抗体和标准化容器均具有高特异性亲和力的中间分子——介质，将标准化容器靶向运输至一组靶抗原。结果表明，与将相同数量的脂质体靶向一种抗原相比，使用抗生物素蛋白-生物素系统将14C标记的脂质体同时靶向三种靶抗原可使脂质体与靶单层的结合增加30%-50%。当靶器官中靶抗原的相对可用性未知时，所开发的方法尤其具有前景。
