Lüthy J, Schlatter C
Z Lebensm Unters Forsch. 1983;177(6):439-43. doi: 10.1007/BF01409672.
The effect of 25 mg histamine, 25 mg tyramine and 5 mg phenylethylamine resp. in apple juice on 27 healthy volunteers was studied using a randomized placebo-controlled double-blind procedure. No statistically significant effect was found with histamine and tyramine, but phenylethylamine produced symptoms like headache, dizziness and discomfort in some volunteers. In a second experiment the effect of four different wines (2 dl) containing naturally several biogenic amines in various amounts (histamine n.d. - 21 ppm; tyramine 1-23 ppm; phenylethylamine n.d. - 6 ppm; putrescine 2-55 ppm) on 20 volunteers was recorded. The percentage of volunteers experiencing symptoms was of the same order of magnitude as in the first experiment. No correlation was found to exist in this second experiment between the occurrence of symptoms and the concentration of biogenic amines in the wine samples.
分别对27名健康志愿者研究了25毫克组胺、25毫克酪胺和5毫克苯乙胺在苹果汁中的作用，采用随机安慰剂对照双盲程序。未发现组胺和酪胺有统计学上的显著作用，但苯乙胺在一些志愿者中产生了如头痛、头晕和不适等症状。在第二个实验中，记录了四种不同葡萄酒（2分升）对20名志愿者的作用，这些葡萄酒天然含有不同量的几种生物胺（组胺未检出 - 21 ppm；酪胺1 - 23 ppm；苯乙胺未检出 - 6 ppm；腐胺2 - 55 ppm）。出现症状的志愿者百分比与第一个实验处于同一数量级。在第二个实验中，未发现症状的出现与葡萄酒样品中生物胺浓度之间存在相关性。
