Zambraski E J, Tucker M S, Lakas C S, Grassl S M, Scanes C G
Am J Physiol. 1984 Jan;246(1 Pt 1):E71-6. doi: 10.1152/ajpendo.1984.246.1.E71.
Exercise is associated with an increase in plasma renin activity (PRA). The purpose of this study was to determine the role of the prostaglandin (PG) and adrenergic pathways in the renin release with exercise in the dog. One group of animals (n = 4) was exercised under control untreated and indomethacin- and meclofenamate- (2 mg/kg) treated conditions. A 155% increase in PRA was not influenced by PG inhibition. In a second group (n = 7) PRA was 1.22 +/- 0.32, 3.29 +/- 1.59, 6.28 +/- 2.85, and 5.30 +/- 2.00 ng ANG I X ml-1 X h-1 at rest and during light, moderate, and heavy exercise, respectively. Guanethidine treatment (15 mg/kg) decreased mean PRA by 41, 50, 70, and 73% at rest and during the three levels of exercise, respectively. In a third group (n = 5) control exercise runs were repeated after metoprolol treatment. Selective beta 1-blockade completely abolished the increment in PRA observed with exercise. These data demonstrate that the elevation of PRA during exercise in the dog is mediated by increased sympathetic nerve activity involving beta 1-receptors and that it is not dependent on alterations in PG synthesis.
运动与血浆肾素活性（PRA）升高有关。本研究的目的是确定前列腺素（PG）和肾上腺素能途径在犬运动时肾素释放中的作用。一组动物（n = 4）在未治疗的对照条件下以及用吲哚美辛和甲氯芬那酸（2 mg/kg）治疗的条件下进行运动。PRA升高155%不受PG抑制的影响。在第二组（n = 7）中，静息时以及轻度、中度和重度运动期间的PRA分别为1.22±0.32、3.29±1.59、6.28±2.85和5.30±2.00 ng ANG I×ml-1×h-1。胍乙啶治疗（15 mg/kg）使静息时以及三个运动水平期间的平均PRA分别降低41%、50%、70%和73%。在第三组（n = 5）中，美托洛尔治疗后重复进行对照运动试验。选择性β1受体阻断完全消除了运动时观察到的PRA升高。这些数据表明，犬运动期间PRA的升高是由涉及β1受体的交感神经活动增加介导的，且不依赖于PG合成的改变。
