Chu C C, Williams D F
Am J Surg. 1984 Feb;147(2):197-204. doi: 10.1016/0002-9610(84)90088-6.
The purpose of this study was to examine the effects of physical configuration and the chemical nature of suture materials on the preferential adherence of bacteria. Ten suture materials of 2-0 (chromic catgut, Dexon, Vicryl, PDS, Mersilene, Tycron, Ethibond, Surgilon, Ethilon, and Prolene) were used. The bacterial strains tested were Staph. aureus and E. coli. The level of bacterial adherence was determined quantitatively by radiolabelled cells and qualitatively by scanning electron microscopy. It was found that the amount of adhered bacteria depended on the type of suture material, the type of bacteria, and the duration of contact. In the group of absorbable sutures, the new PDS sutures exhibited the smallest affinity toward the adherence of both E. coli and Staph. aureus. Dexon sutures had the highest affinity toward these two bacteria. With nonabsorbable sutures, the physical configuration of the sutures contributed more to their ability to attract bacteria than the surface finish. The bacterial adherence on suture materials was also time dependent. Scanning electron microscope morphologic observation also indicated that Staph. aureus adhered on the suture surface in clusters whereas E. coli tended to adhere individually.
本研究的目的是检验缝线材料的物理结构和化学性质对细菌优先黏附的影响。使用了10种2-0缝线材料（铬制肠线、聚羟基乙酸缝线、聚丙交酯乙交酯缝线、聚对二氧环己酮缝线、聚酯纤维缝线、聚酰胺缝线、聚乙烯缝线、聚酯缝线、尼龙缝线和聚丙烯缝线）。所测试的细菌菌株为金黄色葡萄球菌和大肠杆菌。通过放射性标记细胞对细菌黏附水平进行定量测定，并通过扫描电子显微镜进行定性测定。结果发现，黏附细菌的数量取决于缝线材料的类型、细菌的类型以及接触时间。在可吸收缝线组中，新型聚对二氧环己酮缝线对大肠杆菌和金黄色葡萄球菌黏附的亲和力最小。聚羟基乙酸缝线对这两种细菌的亲和力最高。对于不可吸收缝线，缝线的物理结构对其吸引细菌能力的影响比表面光洁度更大。细菌在缝线材料上的黏附也与时间有关。扫描电子显微镜形态学观察还表明，金黄色葡萄球菌以簇状黏附在缝线表面，而大肠杆菌倾向于单独黏附。
