Raynal F, Michot B, Bachellerie J P
FEBS Lett. 1984 Feb 27;167(2):263-8. doi: 10.1016/0014-5793(84)80139-8.
We present the complete sequence of mouse 18 S rRNA. As indicated by comparison with yeast, Xenopus and rat, the conservation of eukaryotic 18 S rRNA sequences is extensive. However, this conservation is far from being uniform along the molecule: most of the base changes and the size differences between species are concentrated at specific locations. Two distinct classes of divergent traces can be detected which differ markedly in their rates of nucleotide substitution during evolution, and should prove valuable in additional comparative analyses, both for eukaryotic taxonomy and for rRNA higher order organization. Mouse and rat 18 S rRNA sequences differ by only 14 point changes over the 1869 nucleotides of the molecule.
我们展示了小鼠18 S rRNA的完整序列。通过与酵母、非洲爪蟾和大鼠进行比较可知，真核生物18 S rRNA序列的保守性很强。然而，这种保守性在整个分子上远非均匀分布：物种之间的大多数碱基变化和大小差异都集中在特定位置。可以检测到两类不同的差异痕迹，它们在进化过程中的核苷酸替换率明显不同，并且在进一步的比较分析中应该会很有价值，无论是对于真核生物分类学还是rRNA的高级结构组织研究。在该分子的1869个核苷酸中，小鼠和大鼠的18 S rRNA序列仅存在14个点突变。
