酵母核糖体RNA基因的结构。I. 酿酒酵母18S核糖体RNA基因的完整核苷酸序列。
The structure of the yeast ribosomal RNA genes. I. The complete nucleotide sequence of the 18S ribosomal RNA gene from Saccharomyces cerevisiae.
作者信息
Rubtsov P M, Musakhanov M M, Zakharyev V M, Krayev A S, Skryabin K G, Bayev A A
出版信息
Nucleic Acids Res. 1980 Dec 11;8(23):5779-94. doi: 10.1093/nar/8.23.5779.
The cloned 18 S ribosomal RNA gene from Saccharomyces cerevisiae have been sequenced, using the Maxam-Gilbert procedure. From this data the complete sequence of 1789 nucleotides of the 18 S RNA was deduced. Extensive homology with many eucaryotic as well as E. coli ribosomal small subunit rRNA (S-rRNA) has been observed in the 3'-end region of the rRNA molecule. Comparison of the yeast 18 S rRNA sequences with partial sequence data, available for rRNAs of the other eucaryotes provides strong evidence that a substantial portion of the 18 S RNA sequence has been conserved in evolution.
利用马克萨姆-吉尔伯特法对酿酒酵母克隆的18S核糖体RNA基因进行了测序。根据这些数据推导得出了18S RNA 1789个核苷酸的完整序列。在rRNA分子的3'端区域观察到与许多真核生物以及大肠杆菌核糖体小亚基rRNA（S-rRNA）有广泛的同源性。将酵母18S rRNA序列与其他真核生物rRNA的部分序列数据进行比较，有力地证明了18S RNA序列的很大一部分在进化过程中得到了保守。
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