从一个基因中的核苷酸序列推断出的大鼠28S核糖体核糖核酸的结构。
The structure of rat 28S ribosomal ribonucleic acid inferred from the sequence of nucleotides in a gene.
作者信息
Chan Y L, Olvera J, Wool I G
出版信息
Nucleic Acids Res. 1983 Nov 25;11(22):7819-31. doi: 10.1093/nar/11.22.7819.
Abstract
The nucleotide sequence of a rat 28S rRNA gene was determined. The 28S rRNA encoded in the gene contains 4718 nucleotides and the molecular weight estimated from the sequence is 1.53 x 10(6). The guanine and cytosine content is 67%. The sequence of rat 28S rRNA diverges appreciably from that of Saccharomyces carlsbergensis 26S rRNA (about 50% identity), but more closely approximates that of Xenopus laevis 28S rRNA (about 75% identity). Rat 28S rRNA is larger than the analogous nucleic acids from yeast (3393 nucleotides) and X, laevis (4110 nucleotides) ribosomes. The additional bases are inserted in specific regions and tend to be rich in guanine and cytosine. 5.8S rRNA can interact with 28S rRNA by extensive hydrogen bonding at two sites near the 5' end of the latter.
摘要
测定了大鼠28S rRNA基因的核苷酸序列。该基因编码的28S rRNA含有4718个核苷酸，根据序列估算的分子量为1.53×10⁶。鸟嘌呤和胞嘧啶的含量为67%。大鼠28S rRNA的序列与卡尔斯伯酵母26S rRNA的序列有明显差异（约50%的同源性），但与非洲爪蟾28S rRNA的序列更为接近（约75%的同源性）。大鼠28S rRNA比来自酵母（3393个核苷酸）和非洲爪蟾（4110个核苷酸）核糖体的类似核酸更大。额外的碱基插入特定区域，且往往富含鸟嘌呤和胞嘧啶。5.8S rRNA可通过在28S rRNA 5'端附近的两个位点广泛形成氢键与28S rRNA相互作用。
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