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在接受致死性照射的细胞转移受体中,只有供体细胞产生抗体的证据。

Evidence that only donor cells produce antibody in a lethally irradiated cell transfer recipient.

作者信息

Francus T, Siskind G W

出版信息

J Immunol Methods. 1982 Sep 30;53(3):345-54. doi: 10.1016/0022-1759(82)90181-8.

DOI:10.1016/0022-1759(82)90181-8
PMID:7142713
Abstract

In a cell transfer system, using the allotype congenic pair C57BL/6 (Ihgb) and B.C-9 (Igha), we established that the antibody response to dinitrophenylated bovine gamma globulin measured by solid state radioimmunoassay was only of donor allotype, both in the primary and in the secondary responses and regardless of the age of the cell donor. The magnitude of the response by allotype congenic recipients was similar to that of syngeneic recipients when either B.C-9 or C57BL/6 were used as donors.

摘要

在一个细胞转移系统中,我们使用同种异型同类系对C57BL/6(Ihgb)和B.C-9(Igha),通过固态放射免疫测定法确定,对二硝基苯基化牛γ球蛋白的抗体反应,在初次和二次反应中均仅为供体同种异型,且与细胞供体的年龄无关。当使用B.C-9或C57BL/6作为供体时,同种异型同类系受体的反应强度与同基因受体的反应强度相似。

相似文献

1
Evidence that only donor cells produce antibody in a lethally irradiated cell transfer recipient.在接受致死性照射的细胞转移受体中,只有供体细胞产生抗体的证据。
J Immunol Methods. 1982 Sep 30;53(3):345-54. doi: 10.1016/0022-1759(82)90181-8.
2
Dominance of an immune response by secondary cells: quantitation by allotype analysis.次级细胞介导的免疫反应优势:通过同种异型分析进行定量
J Immunol. 1980 Jan;124(1):250-4.
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Unidirectional IgG allotype- and isotype-specific suppressor cells in congeneic mice.同源基因小鼠中的单向IgG同种异型和同型特异性抑制细胞。
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Generation in vivo of non-T suppressor cells with the use of anti-allotype antibody.利用抗同种异型抗体在体内产生非T抑制细胞。
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Suppression of antibody responses in allogeneic mice by products of lymphoid tissue. II. Lack of antigenic specificity and immunogenetic requirements of allogeneic suppressive factor (ASF).淋巴组织产物对同种异体小鼠抗体应答的抑制作用。II. 同种异体抑制因子(ASF)的抗原特异性缺失和免疫遗传学要求
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Nude mice are nonpermissive towards the anti-dextran response of congenic cells.裸鼠对同源细胞的抗葡聚糖反应不敏感。
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Immune response against the T-independent antigen alpha (1----3) dextran. II. Occurrence of B gamma memory cells in the course of immunization with the native polysaccharide is T cell dependent.针对非胸腺依赖性抗原α(1----3)葡聚糖的免疫反应。II. 天然多糖免疫过程中Bγ记忆细胞的出现是T细胞依赖性的。
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Lethal graft-versus-host disease in nude mice. I. Establishment of model systems.裸鼠中的致死性移植物抗宿主病。I. 模型系统的建立。
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引用本文的文献

1
Allotype suppression in an adoptive transfer system in adult mice: the specificity and feedback effects of a monoclonal IgG3 anti-(Igh-1b) allotype antibody.成年小鼠过继转移系统中的同种异型抑制:单克隆IgG3抗-(Igh-1b)同种异型抗体的特异性及反馈效应
Immunology. 1984 Mar;51(3):511-6.