小鼠体内抗原特异性细胞反应与抗鼠麻风杆菌感染抵抗力之间缺乏相关性。
A lack of correlation between antigen-specific cellular reactions and resistance to Mycobacterium lepraemurium infection in mice.
作者信息
Curtis J, Adu H O, Turk J L
出版信息
Immunology. 1981 Jun;43(2):293-301.
Abstract
Following infection subcutaneously in the footpad with 10(7) Mycobacterium lepraemurium organisms C57BL mice were able to limit multiplication of organisms at the infection site for the 6 months studied and to limit organism spread to the draining lymph node. Large numbers of organisms were present in the footpad and draining lymph node of BALB/c mice at 6 months. In spite of this difference in local immunity the changes in cellular reactivity to specific antigen as assessed by the delayed footpad response and the in vitro proliferative response of draining lymph node cells were similar in the two strains over the time studied.
摘要
在用10⁷ 鼠麻风杆菌皮下感染足垫后，C57BL小鼠在研究的6个月中能够限制感染部位细菌的增殖，并限制细菌扩散至引流淋巴结。6个月时，BALB/c小鼠的足垫和引流淋巴结中有大量细菌。尽管在局部免疫方面存在这种差异，但在所研究的时间段内，通过足垫迟发型反应和引流淋巴结细胞的体外增殖反应评估的两种品系对特异性抗原的细胞反应性变化相似。
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