Provoost A P, Wolff E D, de Keijzer M H, Molenaar J C
J Pediatr Surg. 1984 Feb;19(1):63-7. doi: 10.1016/s0022-3468(84)80018-4.
The influence of the size of the recipient upon posttransplantation renal function was investigated in an experimental study of inbred rats as well as in a retrospective analysis of juvenile recipients of adult donor kidneys. The experimental study revealed either augmentation of the compensatory response, in case of a juvenile donor kidney transplanted into an adult recipient, or attenuation of this response, in case of an adult donor kidney transplanted into a juvenile recipient. Various workers have reported an augmentation of renal function in humans in case of adult recipients of juvenile donor kidneys. In contrast, attenuation of renal function in case of adult donor kidneys transplanted into juvenile recipients, has not been reported. This attenuation was substantiated in our retrospective clinical study. We found that 3 weeks after transplantation, the absolute creatinine clearance (mL/min) was lower in a group of recipients under 12 years old than in a group of recipients older than 12 years. The experimental as well as the clinical investigation indicated that the size of the recipient plays an important part in the functional outcome after renal transplantation. It appeared that the transplanted kidney behaves like a single organ pertaining to the recipient.
在近交系大鼠的实验研究以及对成年供肾青少年受者的回顾性分析中，研究了受者体型对肾移植后肾功能的影响。实验研究表明，若将幼年供肾移植给成年受者，代偿反应会增强；若将成年供肾移植给幼年受者，代偿反应则会减弱。已有多位研究者报道，幼年供肾的成年受者肾功能会增强。相比之下，成年供肾移植给幼年受者后肾功能减弱的情况尚未见报道。我们的回顾性临床研究证实了这种减弱现象。我们发现，移植后3周，12岁以下受者组的绝对肌酐清除率（mL/分钟）低于12岁以上受者组。实验研究和临床研究均表明，受者体型在肾移植后的功能转归中起着重要作用。移植肾似乎表现得如同受者的一个单独器官。
