Provoost A P, de Keijzer M H, Kort W J, van Aken M, Weyma I M, Wolff E D, Molenaar J C
Transplantation. 1984 Jan;37(1):55-62. doi: 10.1097/00007890-198401000-00016.
Little attention has been paid to the changes in renal function that occur after kidney transplantation when donor and recipient differ markedly in size. We studied this phenomenon after isogeneic kidney transplantation in rats of varying body weight (BW). Renal functional parameters, such as the glomerular filtration rate (GFR), the effective renal plasma flow (ERPF), and the plasma levels of creatinine (Pcr) and urea (Pur) were determined at regular intervals following transplantation. In the initial experimental series, juvenile (BW approximately 150 g) and adult (BW approximately 300 g) rats were used. Four groups of transplant recipients were studied. These consisted of 2 groups of adult recipients of juvenile or adult donor kidneys, and 2 groups of juvenile recipients of juvenile or adult donor kidneys. These 4 groups were compared with adult and juvenile control rats, as well as with unilaterally nephrectomized (NX) rats. A comparison between the 2 groups of juvenile recipients revealed no significant difference in the GFR, ERPF, Pcr, or Pur levels after the transplantation of adult or juvenile donor kidneys. Nor were any significant differences found when comparing the functional parameters of the 2 groups of adult recipients after transplantation of adult or juvenile donor kidneys. The transplanted kidneys generally functioned at a level amounting to 80-90% of the GFR and 90-100% of the ERPF of NX rats of comparable BW. These observations are a clear indication of functional adaptation after kidney transplantation. The compensatory functional response is augmented--in case of a young donor kidney transplanted into an adult recipient, or attenuated--in case of an adult donor kidney transplanted into a juvenile recipient. In an additional experiment, kidneys were transplanted from very young rats (BW approximately 50 g) to adult recipients. It appeared that as early as two weeks after transplantation, renal function had reached adult kidney levels, as observed in the first experimental series. In conclusion, after isogeneic kidney transplantation in rats, the transplanted kidney generally adapts rapidly to the size of the recipient and functions like an inherent part of the recipient's body.
当供体和受体在大小上存在显著差异时，肾移植后发生的肾功能变化很少受到关注。我们在体重不同的大鼠进行同基因肾移植后研究了这一现象。在移植后的定期时间点，测定肾功能参数，如肾小球滤过率（GFR）、有效肾血浆流量（ERPF）以及血浆肌酐（Pcr）和尿素（Pur）水平。在最初的实验系列中，使用了幼年（体重约150克）和成年（体重约300克）大鼠。研究了四组移植受体。其中包括两组成年受体，分别接受幼年或成年供体肾脏；以及两组幼年受体，分别接受幼年或成年供体肾脏。将这四组与成年和幼年对照大鼠以及单侧肾切除（NX）大鼠进行比较。两组幼年受体之间的比较显示，在移植成年或幼年供体肾脏后，GFR、ERPF、Pcr或Pur水平没有显著差异。在比较两组成年受体在移植成年或幼年供体肾脏后的功能参数时，也未发现任何显著差异。移植肾的功能水平一般相当于体重相当的NX大鼠GFR的80 - 90%和ERPF的90 - 100%。这些观察结果清楚地表明肾移植后存在功能适应。在幼年供体肾移植给成年受体的情况下，代偿性功能反应增强；而在成年供体肾移植给幼年受体的情况下，代偿性功能反应减弱。在另一项实验中，将非常年幼大鼠（体重约50克）的肾脏移植给成年受体。结果发现，早在移植后两周，肾功能就已达到第一个实验系列中观察到的成年肾脏水平。总之，在大鼠进行同基因肾移植后，移植肾通常能迅速适应受体的大小，并像受体身体的固有部分一样发挥功能。
