Provoost A P, de Keijzer M H, Kort W J, Wolff E D, Molenaar J C
Kidney Int. 1982 Mar;21(3):459-69. doi: 10.1038/ki.1982.46.
The glomerular filtration rate (GFR) was determined in rats with an isogeneic kidney transplant and compared with that of unilaterally nephrectomized rats. Experiments were carried out in adult rats, 3 months of age, weighing approximately 300 g, as well as in juvenile rats, 6 to 8 weeks of age, weighing approximately 170 g. All donor kidneys were taken from adult rats. The GFR was measured regularly, using a chromium 51-EDTA clearance technique which permitted repeated measurements to be taken in the same animals, during a 15-week followup period. After unilateral nephrectomy the GFR per 100 g body weight (BW) increased compared with that of a single normal kidney. Adult transplant recipients had a GFR per 100 g BW of about 80% of that of unilaterally nephrectomized rats. There was no statistical difference in the GFR when comparing adult recipients of either a normal or a hyperfunctional kidney. When isografts were transplanted to juvenile recipients, there was an initial decrease in the absolute GFR compared with the donor value in the case of a normal adult donor kidney. This decrease was even more pronounced when a hyperfunctioning kidney was transplanted to a juvenile recipient. However, when related to BW the GFR was, as in the adult recipients, about 80% of that of unilaterally nephrectomized juvenile rats. During the followup period the systolic blood pressure was measured regularly by tail plethysmography, in order to detect any blood pressure elevations, which are a frequent complication in adult and pediatric human renal transplantation. However, no hypertension was observed after isogeneic kidney transplantation in the various groups. These results show that the GFR of isogeneically transplanted rat kidneys amounts to about 80% of the maximally attainable level. Isogeneic transplantation of an adult kidney to a juvenile recipient results in a rapid adaptation of the GFR to the smaller size of the body and does not cause an increase in blood pressure.
采用同基因肾移植大鼠测定肾小球滤过率（GFR），并与单侧肾切除大鼠的肾小球滤过率进行比较。实验在3月龄、体重约300g的成年大鼠以及6至8周龄、体重约170g的幼年大鼠中进行。所有供体肾均取自成年大鼠。采用铬51 - 乙二胺四乙酸清除技术定期测量GFR，该技术允许在15周的随访期内在同一动物身上进行重复测量。单侧肾切除后，每100g体重（BW）的GFR比单个正常肾脏时增加。成年移植受体每100g BW的GFR约为单侧肾切除大鼠的80%。比较接受正常或高功能肾脏的成年受体时，GFR无统计学差异。当将同基因移植肾移植给幼年受体时，与正常成年供体肾的供体值相比，绝对GFR最初会下降。当将高功能肾移植给幼年受体时，这种下降更为明显。然而，与BW相关时，GFR与成年受体一样，约为单侧肾切除幼年大鼠的80%。在随访期间，通过尾容积描记法定期测量收缩压，以检测任何血压升高情况，血压升高是成人和儿童肾移植中常见的并发症。然而，在各同基因肾移植组中均未观察到高血压。这些结果表明，同基因移植大鼠肾脏的GFR约为最大可达到水平的80%。将成年肾脏同基因移植给幼年受体可使GFR迅速适应较小的身体尺寸，且不会导致血压升高。
