Sherwin B B, Gelfand M M
Am J Obstet Gynecol. 1984 Mar 1;148(5):552-7. doi: 10.1016/0002-9378(84)90746-4.
In a prospective, double-blind, crossover study, it was found that surgically menopausal women who received an estrogen drug alone and those who were given a combined estrogen-androgen preparation reported a significantly reduced frequency of hot flushes compared to a placebo group (p less than 0.01) coincident with their higher total plasma estrogen levels (p less than 0.01). The administration of testosterone alone, however, was ineffective in alleviating hot flushes, even though these patients had plasma estrogen values that were not different from those of women with intact ovaries. It was proposed that, in women with very low levels of endogenous estrogens, changes in sex hormone-binding globulin (SHBG) concentrations induced by exogenous testosterone may reduce the amount of non-SHBG-bound estrogens, thereby obviating estrogenic effects on hot flushes.
在一项前瞻性、双盲、交叉研究中发现，接受单独雌激素药物治疗的手术绝经女性以及接受雌激素 - 雄激素联合制剂治疗的女性，与安慰剂组相比，潮热频率显著降低（p小于0.01），同时她们的血浆总雌激素水平较高（p小于0.01）。然而，单独给予睾酮对缓解潮热无效，尽管这些患者的血浆雌激素值与卵巢功能正常的女性无异。有人提出，在内源性雌激素水平极低的女性中，外源性睾酮诱导的性激素结合球蛋白（SHBG）浓度变化可能会减少非SHBG结合雌激素的量，从而消除雌激素对潮热的影响。
