Sherwin B B, Gelfand M M, Brender W
Psychosom Med. 1985 Jul-Aug;47(4):339-51. doi: 10.1097/00006842-198507000-00004.
Various parameters of sexual functioning were assessed in a prospective, crossover investigation of 53 surgically menopausal women. Patients randomly received either an estrogen-androgen combined preparation, an estrogen-alone drug, an androgen-alone drug, or a placebo. Also included were a group of women who had undergone hysterectomy and whose ovaries had been left intact. Two treatment phases, each of 3 months' duration, were separated by an intervening placebo month. Additionally, plasma levels of total estrogens and testosterone were assayed four times during the study concurrent with monitoring of sexual behaviors. It was clear that exogenous androgen enhanced the intensity of sexual desire and arousal and the frequency of sexual fantasies in hysterectomized and oophorectomized women. However, there was no evidence that testosterone affected physiologic response or interpersonal aspects of sexual behavior. These findings suggest that the major impact of androgen in women is on sexual motivation and not on sexual activity per se.
在一项针对53名手术绝经女性的前瞻性交叉研究中，对性功能的各项参数进行了评估。患者被随机给予雌激素 - 雄激素联合制剂、单纯雌激素药物、单纯雄激素药物或安慰剂。其中还包括一组接受了子宫切除术但卵巢保留完整的女性。两个为期3个月的治疗阶段中间间隔一个月的安慰剂期。此外，在研究期间对总雌激素和睾酮的血浆水平进行了四次测定，同时监测性行为。很明显，外源性雄激素增强了子宫切除和卵巢切除女性的性欲强度、性唤起及性幻想频率。然而，没有证据表明睾酮会影响性行为的生理反应或人际方面。这些发现表明，雄激素对女性的主要影响在于性动机而非性行为本身。
