McGuinness O P, Spitzer J J
Am J Physiol. 1984 Mar;246(3 Pt 2):R325-30. doi: 10.1152/ajpregu.1984.246.3.R325.
The metabolic clearance rate (MCR) and maximal rate of glycerol removal (Rd max) were determined in anesthetized dogs at two time periods after the intravenous administration of either Escherichia coli endotoxin or saline. The nonisotopic method employed in these studies to determine the MCR of glycerol consisted of a constant infusion of glycerol at three different infusion rates. At each infusion rate a steady-state glycerol concentration was obtained. The reciprocal of the slope of the linear relationship between the glycerol infusion rate and the change in the steady-state arterial glycerol concentration was equal to the MCR of glycerol. Administration of endotoxin significantly decreased the MCR of glycerol, whereas the volume of distribution of glycerol was not altered significantly. The arterial glycerol turnover remained unaltered, whereas arterial glycerol concentration increased after endotoxin administration. The studies demonstrate that the elevated arterial glycerol concentration maintained the rate of glycerol turnover in the face of decreased efficiency of glycerol removal after endotoxin administration.
在静脉注射大肠杆菌内毒素或生理盐水后的两个时间段，对麻醉犬的代谢清除率（MCR）和甘油最大清除率（Rd max）进行了测定。这些研究中用于测定甘油MCR的非同位素方法包括以三种不同输注速率持续输注甘油。在每个输注速率下均获得了稳态甘油浓度。甘油输注速率与稳态动脉甘油浓度变化之间线性关系的斜率的倒数等于甘油的MCR。内毒素给药显著降低了甘油的MCR，而甘油的分布容积未发生显著改变。动脉甘油周转率保持不变，而内毒素给药后动脉甘油浓度升高。这些研究表明，在内毒素给药后甘油清除效率降低的情况下，升高的动脉甘油浓度维持了甘油周转率。
