Buczko G B, Day A, Vanderdoelen J L, Boucher R, Zamel N
Am Rev Respir Dis. 1984 Jan;129(1):12-4. doi: 10.1164/arrd.1984.129.1.12.
Threshold of airway responsiveness to methacholine aerosol was determined in 53 apparently healthy persons. In 18 nonallergic nonsmokers matched according to sex and age to 18 nonallergic smokers, the mean methacholine threshold of airway response (T), as measured using partial flow-volume curves, had a tendency to be greater in nonsmokers, but the difference was not significant for the group as a whole; it was, however, significant for a subset of 9 matched pairs with a cigarette consumption greater than 10 pack-years (mean T nonsmokers, 2.8 mg/ml; smokers, 0.3; p = 0.036). In 17 smokers who stopped smoking for 99 days in average, T was not significantly different for the group as a whole, although the majority of the smokers reported improvement of respiratory symptoms after cessation of smoking. The results of this study indicate that cigarette smoking is associated with increased airways responsiveness to inhaled methacholine and that this effect is dose related.
在53名看似健康的人群中测定了对乙酰甲胆碱气雾剂的气道反应阈值。在根据性别和年龄与18名非过敏性吸烟者相匹配的18名非过敏性非吸烟者中，使用部分流量-容积曲线测量的气道反应平均乙酰甲胆碱阈值（T）在非吸烟者中往往更高，但对于整个组而言差异不显著；然而，对于吸烟量超过10包年的9对匹配对子的子集而言差异显著（非吸烟者平均T为2.8mg/ml；吸烟者为0.3；p = 0.036）。在平均戒烟99天的17名吸烟者中，整个组的T没有显著差异，尽管大多数吸烟者报告戒烟后呼吸道症状有所改善。本研究结果表明，吸烟与气道对吸入乙酰甲胆碱的反应性增加有关，且这种效应与剂量相关。
