三钾二枸橼酸铋预防大鼠胃黏膜损伤
Prevention of gastric mucosal lesions in rats by tri-potassium di-citrato bismuthate.
作者信息
Malandrino S, Campagnoli G, Borsa M, Guidoboni R, Tonon G C
出版信息
Arzneimittelforschung. 1984;34(1):30-1.
PMID:6367754
Abstract
Tri-potassium di-citrato bismuthate given intragastrically to rats 60 min before administration of necrotizing agents such as 85% ethanol, 0.2 N sodium hydroxide or acidified indomethacin, reduced the formation of mucosal lesions dose-dependently. Prostaglandin I2 (PGI2)-like material, determined by bioassay, was higher in the gastric mucosa of animals treated with bismuth subcitrate complex than in control animals.
摘要
在给予坏死剂（如85%乙醇、0.2N氢氧化钠或酸化吲哚美辛）前60分钟给大鼠胃内注射二枸橼酸铋钾，可剂量依赖性地减少黏膜损伤的形成。通过生物测定法测定，次枸橼酸铋复合物处理的动物胃黏膜中前列腺素I2（PGI2）样物质高于对照动物。
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