对乙酰氨基酚和水杨酸盐对大鼠乙醇和阿司匹林所致胃黏膜损伤的预防作用：内源性前列腺素的作用
Prevention of ethanol and aspirin-induced gastric mucosal lesions by paracetamol and salicylate in rats: role of endogenous prostaglandins.
作者信息
Konturek S J, Brzozowski T, Piastucki I, Radecki T
出版信息
Gut. 1982 Jun;23(6):536-40. doi: 10.1136/gut.23.6.536.
Abstract
Paracetamol or sodium salicylate given intragastrically 30 minutes before the administration of absolute ethanol or acidified aspirin dose-dependently reduced the formation of mucosal lesions. The generation of gastric mucosal prostaglandin-like activity increased with ethanol and was completely suppressed by acidified aspirin. Paracetamol or sodium salicylate given alone increased the generation of mucosal prostaglandin-like material. Indomethacin, the prostaglandin synthesis inhibitor, suppressed this effect and inhibited the protective influence of paracetamol or sodium salicylate on the production of gastric lesions.
摘要
在给予无水乙醇或酸化阿司匹林前30分钟经胃内给予对乙酰氨基酚或水杨酸钠，可剂量依赖性地减少黏膜损伤的形成。胃黏膜前列腺素样活性的产生随乙醇增加，并被酸化阿司匹林完全抑制。单独给予对乙酰氨基酚或水杨酸钠可增加黏膜前列腺素样物质的产生。前列腺素合成抑制剂吲哚美辛可抑制此效应，并抑制对乙酰氨基酚或水杨酸钠对胃损伤产生的保护作用。
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