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鼠麻风分枝杆菌体外传代培养物毒力的损害。

Impairment of virulence of in vitro subcultures of Mycobacterium lepraemurium.

作者信息

Turcotte R, Ishaque M

出版信息

Can J Microbiol. 1983 Nov;29(11):1589-91. doi: 10.1139/m83-242.

DOI:10.1139/m83-242
PMID:6367913
Abstract

Mycobacterium lepraemurium was cultivated in vitro on Ogawa egg-yolk medium. The pathogenicity of the third and eighth subcultures for C3H and C57BL mice was compared with that of in vivo grown murine bacilli by evaluating the mean survival time of infected mice. The results strongly suggest that a significant drop of virulence occurs during the in vitro cultivation of M. lepraemurium.

摘要

鼠麻风杆菌在小川蛋黄培养基上进行体外培养。通过评估感染小鼠的平均存活时间，比较了第三代和第八代传代培养物对C3H和C57BL小鼠的致病性与体内生长的鼠杆菌的致病性。结果有力地表明，鼠麻风杆菌在体外培养过程中毒力显著下降。

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Impairment of virulence of in vitro subcultures of Mycobacterium lepraemurium.鼠麻风分枝杆菌体外传代培养物毒力的损害。
Can J Microbiol. 1983 Nov;29(11):1589-91. doi: 10.1139/m83-242.
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