Ishaque M
Rev Can Biol Exp. 1982 Nov;41(3):197-200.
The pathogenicity in Sprague-Dawley rats of Mycobacterium lepraemurium cultivated on egg-yolk medium was investigated. The results show that in vitro grown cultures provoked hugh subcutaneous lepromata in rats similar to those produced by the in vivo grown M. lepraemurium. The acid-fast bacilli isolated from lepromata of rats infected with the in vitro or in vivo grown cultures were microscopically and histopathologically identical to each other.
研究了在蛋黄培养基上培养的鼠麻风分枝杆菌对斯普拉格-道利大鼠的致病性。结果表明，体外培养的菌落在大鼠体内引发了大量皮下麻风瘤，类似于体内生长的鼠麻风分枝杆菌所产生的麻风瘤。从感染了体外或体内培养物的大鼠麻风瘤中分离出的抗酸杆菌在显微镜和组织病理学上彼此相同。
