Nordström C H, Rehncrona S
Acta Anaesthesiol Scand. 1978;22(1):7-12. doi: 10.1111/j.1399-6576.1978.tb01272.x.
The influence of phenobarbitone anaesthesia on cerebral blood flow (CBF) and cerebral metabolic rate for oxygen (CMRo2) during hypothermia (23 degrees C & 27 degrees C) was studied in the rat, using a modification of the Kety & Schmidt (1948) technique and arterio-venous differences for oxygen. Phenobarbitone (150 mg/kg) was found to decrease CMRo2 by 40-60% during hypothermia, when compared to N2O anaesthesia. At a body temperature of 23 degrees C, and during phenobarbitone anaesthesia, CMRo2 was reduced to about 15% of normal control value (about 10.3 ml.100g-1). CBF was reduced to about 50% of the phenobarbitone control value but was similar to the value obtained with N2O anaesthesia at 22 degrees C. It is concluded that the combination of phenobarbitone anaesthesia and hypothermia results in a more pronounced reduction in cerebral metablic rate for oxygen than can be achieved by administration of barbiturates to normothermic animals, or by reducing body temperature by 15 degrees C during superficial anaesthesia.
采用对凯蒂和施密特（1948年）技术的改良方法以及动静脉氧分压差，研究了苯巴比妥麻醉对大鼠低温（23摄氏度和27摄氏度）期间脑血流量（CBF）和脑氧代谢率（CMRo2）的影响。与一氧化二氮麻醉相比，发现苯巴比妥（150毫克/千克）在低温期间可使CMRo2降低40 - 60%。在体温为23摄氏度且处于苯巴比妥麻醉期间，CMRo2降至正常对照值（约10.3毫升·100克-1）的约15%。CBF降至苯巴比妥对照值的约50%，但与22摄氏度时一氧化二氮麻醉所获得的值相似。得出的结论是，苯巴比妥麻醉与低温相结合导致脑氧代谢率的降低比给正常体温动物施用巴比妥类药物或在浅麻醉期间将体温降低15摄氏度所能达到的更为显著。
