Hägerdal M, Keykhah M, Perez E, Harp J R
Acta Anaesthesiol Scand. 1979 Feb;23(1):89-92. doi: 10.1111/j.1399-6576.1979.tb01425.x.
The quantitative effects of a combination of hypothermia and phenobarbital on cerebral oxygen uptake (CMRo2) was studied in rats, curarized and artificially ventilated with 70% nitrous oxide in oxygen. Cerebral blood flow (CBF) was measured with a modification of the KETY & SCHMIDT (1948) technique, using 133xenon as a tracer. Arteriovenous difference in oxygen content over the brain was measured and CMRo2 was calculated. Four groups were studied. Group 1 was a control group. The three experimental groups were injected with phenobarbital intraperitoneally: Group 2 with 50 mg/kg body weight; Group 3 with 150 mg/kg; and Group 4 with 50 mg/kg of phenobarbital, and, in addition, body temperature was lowered to 32 degrees C in this group. CMRo2 in groups 2, 3 and 4 was reduced by 22, 37 and 43%, respectively, compared to Group 1. The changes in CBF were of the same magnitude. In a previous study we have found that CMRo2 decreases by 5% per 1 degree C decrease in body temperature. The value for CMRo2 in Group 4 is close to the value obtained if the effect of 50 mg/kg body weight of phenobarbital on CMRo2 is added to the effect of a temperature reduction of 5 degrees C. It is concluded that the effects of barbiturates and hypothermia on CMRo2 are additive.
在使用箭毒麻痹并以含70%氧化亚氮的氧气进行人工通气的大鼠中，研究了低温与苯巴比妥联合使用对脑氧摄取量（CMRo2）的定量影响。采用KETY & SCHMIDT（1948年）技术的改良方法，以133氙作为示踪剂测量脑血流量（CBF）。测量脑动静脉氧含量差并计算CMRo2。研究了四组。第一组为对照组。三个实验组腹腔注射苯巴比妥：第二组注射50mg/kg体重；第三组注射150mg/kg；第四组注射50mg/kg苯巴比妥，此外该组体温降至32摄氏度。与第一组相比，第二、三、四组的CMRo2分别降低了22%、37%和43%。CBF的变化幅度相同。在先前的一项研究中我们发现，体温每降低1摄氏度，CMRo2下降5%。第四组的CMRo2值接近于将50mg/kg体重苯巴比妥对CMRo2的影响与体温降低5摄氏度的影响相加所得到的值。得出的结论是，巴比妥类药物和低温对CMRo2的影响是相加的。
