McAreavey D, Brown W B, Murray G D, Robertson J I
Clin Sci (Lond). 1984 May;66(5):545-9. doi: 10.1042/cs0660545.
Exchangeable sodium (NaE), plasma active renin concentration and blood pressure were measured in rats with a sole remaining kidney before and after the development of hypertension induced by clipping of the single renal artery and again after unclipping. Control observations were made in sham-clipped and sham-unclipped uninephrectomized rats. Renal artery clipping caused hypertension and expansion of NaE, the latter being sustained throughout the 6 weeks during which the renal artery was constricted. Hypertension in the clipped rats was progressive over 6 weeks, whereas the expansion of NaE was not; thus the two measurements were not significantly correlated. Two rats which remained normotensive after clipping did not show expansion of NaE. Plasma active renin was elevated in comparison with the sham-clipped controls on the day after clipping, but not thereafter. Unclipping in hypertensive rats was followed by a return of NaE and blood pressure to control values. Both the sustained expansion of NaE and the transient rise in active renin probably contribute to the development of hypertension in this model, but neither alone nor together do they provide a full satisfactory explanation.
在单肾大鼠中，测量了单肾动脉夹闭诱发高血压前后以及解除夹闭后的可交换钠（NaE）、血浆活性肾素浓度和血压。对假夹闭和假解除夹闭的单肾切除大鼠进行了对照观察。肾动脉夹闭导致高血压和NaE增加，在肾动脉收缩的整个6周内，后者持续存在。夹闭大鼠的高血压在6周内呈进行性发展，而NaE的增加并非如此；因此，这两项测量结果无显著相关性。两只夹闭后仍保持血压正常的大鼠未出现NaE增加。夹闭后第1天，与假夹闭对照组相比，血浆活性肾素升高，但此后未再升高。高血压大鼠解除夹闭后，NaE和血压恢复到对照值。NaE的持续增加和活性肾素的短暂升高可能都促成了该模型中高血压的发生，但单独或共同作用都不能提供完全令人满意的解释。
