Ledingham J M, Simpson F O
Clin Exp Hypertens (1978). 1979;1(6):831-47. doi: 10.3109/10641967909068642.
Total exchangeable sodium (Nae) was measured by wholebody counting of 22Na in 1- and 2-kidney Goldblatt rats before, and for 12 weeks after, renal artery clipping. In 1-kidney Goldblatt rats, Nae relative to body weight increased immediately after the clipping procedure and then fell though not to normal levels; from the 10th to the 12th week it again rose rapidly, probably secondary to vascular damage. In 2-kidney Goldblatt rats, Nae relative to body weight increased immediately after the clipping procedure but by the 5th day it was back to normal and remained normal thereafter. Consideration of the values for absolute Nae (i.e. expressed in mmol per rat) casts some doubt on the reality of the sodium 'retention', except in the 1-kidney Goldblatt rats in the later stages of their hypertension. Immediately after surgery temporary loss of weight (presumably mainly affecting fat stores and muscle) probably accounts for much of the rise in Nae relative to body weight.
通过对单侧肾和双侧肾肾动脉夹闭的戈德布拉特大鼠进行体内²²Na计数，测量了其总可交换钠（Nae）。在夹闭手术前以及术后12周内进行测量。在单侧肾肾动脉夹闭的戈德布拉特大鼠中，夹闭手术后Nae相对于体重立即增加，然后下降，但未降至正常水平；从第10周到第12周，它再次迅速上升，可能继发于血管损伤。在双侧肾肾动脉夹闭的戈德布拉特大鼠中，夹闭手术后Nae相对于体重立即增加，但到第5天时恢复正常并此后一直保持正常。考虑绝对Nae值（即每只大鼠以毫摩尔表示），除了在单侧肾肾动脉夹闭的戈德布拉特大鼠高血压后期阶段外，对钠“潴留”的实际情况存在一些疑问。手术后体重立即暂时减轻（可能主要影响脂肪储备和肌肉）可能是Nae相对于体重增加的主要原因。
