Katayama S, Brownscheidle C M, Wootten V, Lee J B, Shimaoka K
Diabetes. 1984 Apr;33(4):324-7. doi: 10.2337/diab.33.4.324.
The proestrus preovulatory luteinizing hormone (LH) surge was absent or delayed in more than 56% of untreated streptozotocin-diabetic rats. Absence of LH surge was associated with anovulation. Insulin treatment for 10-14 days restored the diminished surge and ovulation frequency. Pituitary LH release in response to exogenous gonadotropin-releasing hormone administration in diabetic rats was not different from controls. Impaired hypothalamic function may comprise the basis for the increased incidence of infertility in diabetes mellitus.
超过56%未经治疗的链脲佐菌素诱导的糖尿病大鼠缺乏发情前期排卵前促黄体生成素（LH）高峰或其出现延迟。LH高峰缺失与无排卵相关。胰岛素治疗10 - 14天可恢复减弱的高峰及排卵频率。糖尿病大鼠对外源性促性腺激素释放激素给药的垂体LH释放与对照组无差异。下丘脑功能受损可能是糖尿病中不孕症发病率增加的基础。
