Taniguchi Y, Hasegawa Y, Igarashi M
Nihon Sanka Fujinka Gakkai Zasshi. 1984 Apr;36(4):557-63.
In order to clarify the mechanism of the failure of reproductive function in diabetic rats, the hypothalamic pituitary-ovarian function in streptozotocin-induced diabetic mature female rats was investigated. Estrous cycle patterns were disturbed in diabetic rats and these rats showed constant diestrus. In diabetic rats no preovulatory LH or FSH-surge were observed on presumed proestrus, and the number of ovulated ova and the weights of ovary and uterus were significantly less than those seen in control rats on presumed estrus. The response of the pituitary gland to LH-RH in diabetic rats and diabetic castrated rats was not significantly different from that in control rats on diestrous day and castrated control rats, respectively. However, the response of the hypothalamic-pituitary axis to steroidal feedback in diabetic castrated rats was significantly less than that in castrated control rats. The number of ovulated ova and ovarian growth induced by hCG in diabetic rats were also significantly lower than those in control rats. These results indicate that the impaired site in streptozotocin diabetic rats is not the pituitary gland, but the ovary and hypothalamic-pituitary function.
为了阐明糖尿病大鼠生殖功能衰竭的机制，研究了链脲佐菌素诱导的糖尿病成熟雌性大鼠的下丘脑 - 垂体 - 卵巢功能。糖尿病大鼠的发情周期模式紊乱，这些大鼠表现为持续的间情期。在假定的动情前期，糖尿病大鼠未观察到排卵前促黄体生成素（LH）或促卵泡生成素（FSH）高峰，并且在假定的发情期，糖尿病大鼠的排卵卵子数量、卵巢和子宫重量明显低于对照大鼠。糖尿病大鼠和糖尿病去势大鼠垂体对促黄体生成素释放激素（LH - RH）的反应分别与间情期对照大鼠和去势对照大鼠无显著差异。然而，糖尿病去势大鼠下丘脑 - 垂体轴对甾体反馈的反应明显低于去势对照大鼠。糖尿病大鼠中由人绒毛膜促性腺激素（hCG）诱导的排卵卵子数量和卵巢生长也明显低于对照大鼠。这些结果表明，链脲佐菌素糖尿病大鼠的受损部位不是垂体，而是卵巢和下丘脑 - 垂体功能。
