Chew-Lim M, Scott T, Webb H E
Acta Neuropathol. 1978 Jan 19;41(1):55-9. doi: 10.1007/BF00689557.
An ultrastructural study of cerebellar lesions involving axonal and myelin degeneration induced in adult Swiss A2G mice by 3 intraperitoneal inoculations of avirulent Semliki Forest virus is described. Cerebellar white matter samples examined by light and electron miscroscopy 21 days after the first virus infection revealed microcystic areas, degenerating axons, macrophages containing myelin debris as well as normal elements. By light microscopy foci of myelin loss were apparent. At 28 days groups of degenerating axons were apparent in the white matter. No virus was seen in any of the sections.
本文描述了对成年瑞士A2G小鼠进行三次腹腔接种无毒力的Semliki森林病毒后诱导的涉及轴突和髓鞘变性的小脑病变的超微结构研究。首次病毒感染21天后，通过光镜和电镜检查的小脑白质样本显示有微囊区、变性轴突、含有髓鞘碎片的巨噬细胞以及正常成分。通过光镜可见明显的髓鞘丢失灶。在28天时，白质中可见成组的变性轴突。在任何切片中均未见到病毒。
