Woolfe S N, Kenney E B, Hume W R, Carranza F A
J Clin Periodontol. 1984 Mar;11(3):159-65. doi: 10.1111/j.1600-051x.1984.tb01319.x.
The effect of ascorbic acid megadoses on gingival clinical parameters and vitamin content of blood and gingival tissue was studied. 10 nondeficient individuals, carefully matched according to age, periodontal status, and oral hygiene level, were divided into 2 groups: one received 250 mg q.i.d. of ascorbic acid and the other a placebo. After 1 week on the tablet all patients were scaled and root planed and received oral hygiene instructions. Blood samples and clinical parameters were obtained at baseline and 2, 6, and 7 weeks after. A gingival biopsy was taken at week 6. Correlations between the clinical parameters and the ascorbic acid levels at the different time periods revealed no significant differences between the vitamin and the placebo groups, therefore suggesting that the use of megadoses of vitamin C in normal human subjects does not have a predictable or strong effect on the gingival response to initial therapy.
研究了大剂量抗坏血酸对牙龈临床参数以及血液和牙龈组织中维生素含量的影响。10名非维生素缺乏个体，根据年龄、牙周状况和口腔卫生水平进行精心匹配，分为两组：一组每天四次服用250毫克抗坏血酸，另一组服用安慰剂。服用片剂1周后，所有患者均接受龈下刮治和根面平整，并接受口腔卫生指导。在基线以及之后的第2、6和7周采集血样并记录临床参数。在第6周进行牙龈活检。不同时间段临床参数与抗坏血酸水平之间的相关性显示，维生素组和安慰剂组之间无显著差异，因此表明在正常人类受试者中使用大剂量维生素C对牙龈对初始治疗的反应没有可预测的或强烈的影响。
