Vogel R I, Lamster I B, Wechsler S A, Macedo B, Hartley L J, Macedo J A
J Periodontol. 1986 Aug;57(8):472-9. doi: 10.1902/jop.1986.57.8.472.
A double-blind study was undertaken to determine the effects of megadose ascorbic acid supplementation on plasma ascorbate levels, polymorphonuclear neutrophil (PMN) chemotaxis and clinical and biochemical determinations of inflammatory progression in individuals with a mean daily ascorbate intake level of approximately twice the recommended daily allowances. Results indicate that although the group receiving ascorbate supplementation demonstrated a significant increase in plasma levels of the vitamin as compared to a placebo group, no significant differences with respect to PMN chemotaxis or responses to experimental gingivitis were found between the groups.
进行了一项双盲研究，以确定补充大剂量抗坏血酸对血浆抗坏血酸盐水平、多形核中性粒细胞（PMN）趋化性以及平均每日抗坏血酸摄入量约为推荐每日摄入量两倍的个体炎症进展的临床和生化测定的影响。结果表明，尽管与安慰剂组相比，接受抗坏血酸补充的组血浆中该维生素水平显著升高，但两组之间在PMN趋化性或对实验性牙龈炎的反应方面未发现显著差异。
