肿瘤细胞上的外来抗原再探讨。

Alien antigens on tumour cells revisited.

作者信息

Pierotti M A, Parmiani G

出版信息

J Immunogenet. 1984 Feb;11(1):1-7. doi: 10.1111/j.1744-313x.1984.tb01034.x.

DOI:10.1111/j.1744-313x.1984.tb01034.x

Abstract

New findings on the detection of alien histocompatibility antigens (AHA) on tumour cells are reviewed. Three points are discussed, namely: (1) isolation and molecular characterization of AHA; (2) frequency of expression of AHA by tumour cells, and (3) mechanisms of expression of AHA. Mechanisms of expressions of AHA are particularly discussed in the light of the recent advances in the understanding of the molecular genetic organization of H-2 antigens. Gene conversion involving coding or non-coding sequences might be responsible for the appearance of unexpected H-2 determinants on cancer cells.

摘要

本文综述了肿瘤细胞中外源组织相容性抗原（AHA）检测的新发现。讨论了三点，即：（1）AHA的分离和分子特征；（2）肿瘤细胞中AHA的表达频率，以及（3）AHA的表达机制。鉴于对H-2抗原分子遗传组织的理解方面的最新进展，特别讨论了AHA的表达机制。涉及编码或非编码序列的基因转换可能是癌细胞上出现意外H-2决定簇的原因。