实验性变应性神经炎中免疫复合物的检测

Detection of immune complexes in experimental allergic neuritis.

作者信息

Koh C S, Nakano T, Tsukada N, Yanagisawa N, Okano A, Taketomi T

出版信息

J Neurol Sci. 1984 Feb;63(2):229-39. doi: 10.1016/0022-510x(84)90198-9.

Abstract

Circulating immune complexes were assayed in the sera of animals with experimental allergic neuritis (EAN), and immunofluorescent staining and immunohistological examination were performed to clarify the role of immune complexes in the pathogenesis of EAN. The level of immune complexes in the sera of animals with clinical signs of EAN was from 1:32 to 1:64. Control animals showed a titer of immune complexes from 1:2 to 1:4. Animals with EAN showed deposition of immune complexes, which were detected by FITC-conjugated anti-rat IgG or C3-complement, in the vessels of the peripheral nerve. These findings suggest that immune complexes may contribute to the immunopathogenesis of EAN.

摘要

对患有实验性变态反应性神经炎（EAN）的动物血清中的循环免疫复合物进行了检测，并进行了免疫荧光染色和免疫组织学检查，以阐明免疫复合物在EAN发病机制中的作用。出现EAN临床症状的动物血清中免疫复合物水平为1:32至1:64。对照动物的免疫复合物滴度为1:2至1:4。患有EAN的动物在外周神经血管中显示出免疫复合物的沉积，这些沉积可通过异硫氰酸荧光素（FITC）偶联的抗大鼠IgG或C3补体检测到。这些发现表明免疫复合物可能参与了EAN的免疫发病机制。