Tsukada N, Koh C S, Yanagisawa N, Taketomi T, Behan P O
Acta Neuropathol. 1985;66(4):274-82. doi: 10.1007/BF00690959.
It was demonstrated that New Zealand Albino rabbits sensitized to galactocerebroside had high levels of anti-galactocerebroside antibody and of immune complexes. The rabbits was high titers of immune complexes developed demyelination in the peripheral nerves. Lesion were produced in the peripheral nerves of mice by the i.m. injection of galactocerebroside immune complexes. The lesions were characterized by axonal degeneration, infiltrating macrophages containing myelin debris, and an inflammatory infiltrate of polymorphonuclear and mononuclear cells. Rabbit immunoglobulin and mouse C3 were observed around the endoneural blood vessels. These results suggest that galactocerebroside immune complexes may play a role in the pathogenesis of mouse peripheral nerve lesions, due to the production of vasculomyelinopathy.
已证实，对半乳糖脑苷脂致敏的新西兰白化兔具有高水平的抗半乳糖脑苷脂抗体和免疫复合物。该兔体内高滴度的免疫复合物导致外周神经脱髓鞘。通过肌肉注射半乳糖脑苷脂免疫复合物在小鼠外周神经中产生病变。这些病变的特征是轴突变性、含有髓鞘碎片的浸润性巨噬细胞以及多形核和单核细胞的炎性浸润。在内神经血管周围观察到兔免疫球蛋白和小鼠C3。这些结果表明，由于血管性髓鞘病的产生，半乳糖脑苷脂免疫复合物可能在小鼠外周神经病变的发病机制中起作用。
