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松弛素

Relaxin.

作者信息

Weiss G

出版信息

Annu Rev Physiol. 1984;46:43-52. doi: 10.1146/annurev.ph.46.030184.000355.

DOI:10.1146/annurev.ph.46.030184.000355
PMID:6370116
Abstract

The past decade has seen major advances in understanding the chemistry of relaxin. Sensitive radioimmunoassays have allowed description of the secretion patterns of relaxin in several species. It is likely that technical advances in the near future will provide significant quantities of human relaxin as well as monoclonal antibodies to various relaxins. These tools should clarify the physiological roles of relaxin, elucidate its mechanisms of action, and enable testing of human relaxin as a potentially useful pharmacological agent.

摘要

在过去十年里,人们对松弛素化学性质的理解取得了重大进展。灵敏的放射免疫测定法已能描述多种物种中松弛素的分泌模式。在不久的将来,技术进步可能会提供大量的人松弛素以及针对各种松弛素的单克隆抗体。这些工具应能阐明松弛素的生理作用,阐释其作用机制,并能将人松弛素作为一种潜在有用的药物进行试验。

相似文献

1
Relaxin.松弛素
Annu Rev Physiol. 1984;46:43-52. doi: 10.1146/annurev.ph.46.030184.000355.
2
Relaxin--a review.松弛素——综述
Aust N Z J Obstet Gynaecol. 1981 Nov;21(4):195-202. doi: 10.1111/j.1479-828x.1981.tb00130.x.
3
Relaxin receptors and a study of the physiological roles of relaxin.
Adv Exp Med Biol. 1982;143:289-314. doi: 10.1007/978-1-4613-3368-5_27.
4
The role of the hormone relaxin in human reproduction and pelvic girdle relaxation.激素松弛素在人类生殖及骨盆带松弛中的作用。
Scand J Rheumatol Suppl. 1991;88:7-15.
5
Relaxin as a new hormone.松弛素作为一种新的激素。
Endocr Rev. 1982 Winter;3(1):62-90. doi: 10.1210/edrv-3-1-62.
6
The physiological effects of relaxin during pregnancy: studies in rats and pigs.松弛素在孕期的生理作用:大鼠和猪的研究
Oxf Rev Reprod Biol. 1993;15:143-89.
7
Biology and biochemistry of myometrial contractility and cervical maturation.子宫肌层收缩性与宫颈成熟的生物学及生物化学
Semin Perinatol. 1981 Jul;5(3):216-35.
8
Interpubic ligament regression in relaxin-treated virgin and primiparous, post-partum mice.
Endocrinology. 1960 Nov;67:668-73. doi: 10.1210/endo-67-5-668.
9
Regulation of relaxin secretion.松弛素分泌的调节。
Tohoku J Exp Med. 1966 Nov;90(3):219-32. doi: 10.1620/tjem.90.219.
10
The role of relaxin in human reproduction.松弛素在人类生殖中的作用。
Clin Reprod Fertil. 1983 Jun;2(2):77-95.

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Entropic elastic processes in protein mechanisms. II. Simple (passive) and coupled (active) development of elastic forces.蛋白质机制中的熵弹性过程。II. 弹力的简单(被动)和耦合(主动)发展
J Protein Chem. 1988 Apr;7(2):81-114. doi: 10.1007/BF01025240.
6
Debilitating "functional" bowel disease controlled by leuprolide acetate, gonadotropin-releasing hormone (GnRH) analog.由醋酸亮丙瑞林(一种促性腺激素释放激素(GnRH)类似物)控制的使人虚弱的“功能性”肠病。
Dig Dis Sci. 1989 May;34(5):761-6. doi: 10.1007/BF01540350.
7
Effects of porcine relaxin on contraction, membrane response and cyclic AMP content in rat myometrium in comparison with the effects of isoprenaline and forskolin.与异丙肾上腺素和福斯高林的作用相比,猪松弛素对大鼠子宫肌层收缩、膜反应和环磷酸腺苷含量的影响。
Br J Pharmacol. 1991 Dec;104(4):950-60. doi: 10.1111/j.1476-5381.1991.tb12532.x.
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Chronic intestinal pseudoobstruction in a patient with heart-lung transplant. Therapeutic effect of leuprolide acetate.心肺移植患者的慢性肠假性梗阻。醋酸亮丙瑞林的治疗效果。
Dig Dis Sci. 1992 Nov;37(11):1761-8. doi: 10.1007/BF01299872.