MacLennan A H
University Department of Obstetrics & Gynaecology, University of Adelaide, South Australia.
Scand J Rheumatol Suppl. 1991;88:7-15.
Relaxin is a polypeptide hormone produced in the human female by the corpus luteum of pregnancy and the decidua. In the male it is produced in the prostate and is present in human semen. It probably plays a paracrine role in the human and thus peripheral serum levels may not always reflect its activity. Although a large amount of pelvic relaxation is necessary in some species, such as rodents, for successful parturition, little increased joint mobility is necessary at human parturition. However, some women experience much greater degrees of pelvic girdle relaxation on average and this appears to be more common in the Scandinavian countries than the rest of the world. Studies are presented showing an association between high serum relaxin levels and symptom giving pelvic girdle relaxation during pregnancy. It is not yet possible to measure relaxin receptors in these women but high levels of relaxin or a susceptibility to relaxin may be contributing to this problem. Before considering manipulating relaxin levels or down grading relaxin receptors to try to improve the symptoms of pelvic girdle relaxation it is important to understand the many other roles of relaxin in the human. Evidence is presented that suggests that relaxin may have significant roles in sperm motility, fertilisation, implantation, uterine growth and accommodation, the control of myometrial activity to prevent preterm labour, cervical ripening and the facilitation of labour. The management of pelvic girdle relaxation is discussed.
松弛素是一种多肽激素，由人类女性孕期的黄体和蜕膜产生。在男性体内，它由前列腺产生，并存在于人类精液中。它可能在人体内发挥旁分泌作用，因此外周血清水平可能并不总是反映其活性。虽然在某些物种（如啮齿动物）中，大量的骨盆松弛对于成功分娩是必要的，但在人类分娩时，关节活动度几乎不需要增加。然而，一些女性平均经历的骨盆带松弛程度要大得多，而且这在斯堪的纳维亚国家似乎比世界其他地区更常见。有研究表明，孕期血清松弛素水平高与骨盆带松弛症状之间存在关联。目前尚无法测量这些女性体内的松弛素受体，但高水平的松弛素或对松弛素的易感性可能是导致这一问题的原因。在考虑调节松弛素水平或降低松弛素受体水平以试图改善骨盆带松弛症状之前，了解松弛素在人体内的许多其他作用非常重要。有证据表明，松弛素可能在精子活力、受精、着床、子宫生长和适应、控制子宫肌层活动以预防早产、宫颈成熟和促进分娩等方面发挥重要作用。本文还讨论了骨盆带松弛的管理。
