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人乳腺癌和支气管癌。体内和体外分泌与胰岛素免疫交叉反应的物质。

Human mammary and bronchial carcinomas. In vivo and in vitro secretion of substances immunologically cross-reactive with insulin.

作者信息

Pavelić L, Pavelić K, Vuk-Pavlović S

出版信息

Cancer. 1984 Jun 1;53(11):2467-71. doi: 10.1002/1097-0142(19840601)53:11<2467::aid-cncr2820531117>3.0.co;2-#.

DOI:10.1002/1097-0142(19840601)53:11<2467::aid-cncr2820531117>3.0.co;2-#
PMID:6370415
Abstract

In the blood of two patients suffering from mammary carcinoma and one from bronchial carcinoma, the levels of substances immunologically cross-reactive with insulin (SICRI) were high before surgery; after surgery normoinsulinemia was restored. Direct evidence of SICRI production by the cultured tumorous tissue is presented. Strong daily SICRI fluctuations were observed, and it is proposed that the fluctuations induce instantaneous hypoglycemias experienced by some tumorous patients.

摘要

在两名乳腺癌患者和一名支气管癌患者的血液中，术前与胰岛素免疫交叉反应的物质（SICRI）水平较高；术后恢复了正常胰岛素血症。文中给出了培养的肿瘤组织产生SICRI的直接证据。观察到SICRI每日有强烈波动，并提出这些波动会诱发一些肿瘤患者经历的瞬间低血糖症。

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1
Human mammary and bronchial carcinomas. In vivo and in vitro secretion of substances immunologically cross-reactive with insulin.人乳腺癌和支气管癌。体内和体外分泌与胰岛素免疫交叉反应的物质。
Cancer. 1984 Jun 1;53(11):2467-71. doi: 10.1002/1097-0142(19840601)53:11<2467::aid-cncr2820531117>3.0.co;2-#.
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Biol Chem Hoppe Seyler. 1990 Mar;371(3):249-54. doi: 10.1515/bchm3.1990.371.1.249.
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Isolation and purification of a substance immunologically cross-reactive with insulin (SICRI) from tumor tissue.从肿瘤组织中分离和纯化与胰岛素具有免疫交叉反应性的物质（SICRI）。
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Horm Metab Res. 1972 Mar;4(2):58-62. doi: 10.1055/s-0028-1094099.

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