Baltić V, Levanat S, Petek M, Bratić-Mikes V, Pavelić K, Vuk-Pavlović S
Oncology. 1985;42(3):174-8. doi: 10.1159/000226026.
Results of a survey of concentrations of substances immunologically cross-reactive with insulin (SICRI), glucose and growth hormone in preprandially drawn blood of 84 patients suffering from bronchial epidermoid, microcellular and adenocarcinomas and 22 patients from sarcoidosis, tuberculosis and obstructive bronchitis are presented. In all these diseases, tissue proliferation takes place. Supranormal SICRI concentrations were frequently associated with these diseases, whereas concentrations of glucose and growth hormone remained unaffected; this shows that physiological effects of SICRI in these diseases differ from the effects in patients suffering from some lympho-proliferative and solid tumors. These results indicate that elevated levels of circulating substances detectable by insulin-specific radioimmunoassay can accompany both malignant and nonmalignant proliferation in lungs.
本文呈现了对84例支气管表皮样癌、微细胞癌和腺癌患者以及22例结节病、肺结核和阻塞性支气管炎患者餐前抽取血液中与胰岛素免疫交叉反应物质（SICRI）、葡萄糖和生长激素浓度的调查结果。在所有这些疾病中，均会发生组织增殖。SICRI浓度超常常与这些疾病相关，而葡萄糖和生长激素的浓度未受影响；这表明SICRI在这些疾病中的生理作用不同于在一些淋巴增殖性和实体瘤患者中的作用。这些结果表明，通过胰岛素特异性放射免疫测定法可检测到的循环物质水平升高可伴随肺部的恶性和非恶性增殖。
