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植物血凝素对淋巴细胞的激活作用：不同制剂的定量比较

Phytohemagglutinin activation of lymphocytes: quantitative comparison of different preparations.

作者信息

Eddie-Quartey A C, Gross N J

出版信息

Am J Clin Pathol. 1978 Mar;69(3):326-8. doi: 10.1093/ajcp/69.1.326.

DOI:10.1093/ajcp/69.1.326
PMID:637045
Abstract

Lymphocytes from 12 normal subjects were stimulated in vitro with several concentrations of six commercial preparations of phytohemagglutinin and one column-purified preparation. All preparations produced activation profiles that were highly concentration dependent, with diminished activation at concentrations greater than the optimal concentration. The preparations differed markedly in their mitogenic capacities. Several concentrations of phytohemagglutinin should be employed when lymphocyte activation in vitro is studied as an index of cell-mediated immunity.

摘要

用六种市售植物血凝素制剂和一种柱纯化制剂的几种浓度，对12名正常受试者的淋巴细胞进行体外刺激。所有制剂产生的激活曲线都高度依赖于浓度，在高于最佳浓度时激活作用减弱。这些制剂的促有丝分裂能力有显著差异。当研究体外淋巴细胞激活作为细胞介导免疫指标时，应使用几种浓度的植物血凝素。

相似文献

1
Phytohemagglutinin activation of lymphocytes: quantitative comparison of different preparations.植物血凝素对淋巴细胞的激活作用：不同制剂的定量比较
Am J Clin Pathol. 1978 Mar;69(3):326-8. doi: 10.1093/ajcp/69.1.326.
2
Lymphocyte responsiveness to phytohemagglutinin (PHA): quantitative aspects and reproducibility.淋巴细胞对植物血凝素（PHA）的反应性：定量方面及可重复性。
J Reticuloendothel Soc. 1974 Aug;16(2):114-21.
3
Adenosine metabolism in phytohemagglutinin-stimulated human lymphocytes.植物血凝素刺激的人淋巴细胞中的腺苷代谢
J Clin Invest. 1976 Sep;58(3):654-66. doi: 10.1172/JCI108512.
4
Inability of highly purified preparations of human chorionic gonadotropin to inhibit the phytohemagglutinin-induced stimulation of lymphocytes.高纯度人绒毛膜促性腺激素制剂无法抑制植物血凝素诱导的淋巴细胞刺激。
FEBS Lett. 1975 May 15;53(3):309-12. doi: 10.1016/0014-5793(75)80043-3.
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Lymphocyte transformation induced by autologous cells. II. Stimulation by mitogen-induced lymphoblasts.自体细胞诱导的淋巴细胞转化。II. 有丝分裂原诱导的淋巴母细胞的刺激作用。
J Exp Med. 1973 Mar 1;137(3):799-806. doi: 10.1084/jem.137.3.799.
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Effect of Crude and Purified hCG on Lymphocyte Blastogenesis.粗制和纯化的人绒毛膜促性腺激素对淋巴细胞增殖的影响。
Obstet Gynecol. 1976 May;47(5):557-61.
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In vitro activation of cyclophosphamide by phytohemagglutinin-stimulated lymphocytes.植物血凝素刺激的淋巴细胞对环磷酰胺的体外激活作用。
Am J Med Sci. 1972 Oct;264(4):307-12. doi: 10.1097/00000441-197210000-00008.
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Inhibition of phytohemagglutinin-induced lymphocyte transformation by globulins; lack of correlation with phytohemagglutinin precipitation by serum proteins.球蛋白对植物血凝素诱导的淋巴细胞转化的抑制作用；与血清蛋白对植物血凝素的沉淀作用缺乏相关性。
J Immunol. 1972 Mar;108(3):845-7.
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[Effect of methotrexate on DNA synthesis in human lymphocytes stimulated with phytohemagglutinin].[甲氨蝶呤对植物血凝素刺激的人淋巴细胞中DNA合成的影响]
Boll Soc Ital Biol Sper. 1970 Feb 28;46(4):167-70.
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[Inhibition of DNA biosynthesis in human lymphocytes by alpha 1-antitrypsin].α1-抗胰蛋白酶对人淋巴细胞DNA生物合成的抑制作用
C R Acad Hebd Seances Acad Sci D. 1977 Dec 19;285(16):1499-501.

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