人体中β2-微球蛋白与妥布霉素肾脏排泄率之间的相互作用。
Interaction between the renal excretion rates of beta 2-microglobulin and tobramycin in man.
作者信息
Vree T B, Zweens K, Huige P J, Guelen P J, Jongman-Nix B
出版信息
Clin Chim Acta. 1984 Mar 27;138(1):49-57. doi: 10.1016/0009-8981(84)90353-x.
The renal excretion rate of beta 2-microglobulin in man is 127 +/- 98 ng/min at alkaline urine pH (pH 7). Tobramycin, up to intravenous doses of 160 mg (2 mg/kg) does not increase the renal excretion rate of beta 2-microglobulin. Tobramycin must have less affinity than gentamicin for the tubular system for active reabsorption of amino groups containing organic compounds. Due to this reduced affinity tobramycin will be absorbed less by the proximal tubular cells, which may be one of the reasons for tobramycin being less toxic than gentamicin. beta 2-Microglobulin excretion can be used as a parameter for the relative binding affinity of aminoglycosides.
在尿液pH呈碱性（pH 7）时，人体β2-微球蛋白的肾脏排泄率为127±98纳克/分钟。静脉注射剂量高达160毫克（2毫克/千克）的妥布霉素不会增加β2-微球蛋白的肾脏排泄率。对于含有氨基的有机化合物的主动重吸收，妥布霉素对肾小管系统的亲和力必定低于庆大霉素。由于这种亲和力降低，妥布霉素被近端肾小管细胞吸收较少，这可能是妥布霉素毒性低于庆大霉素的原因之一。β2-微球蛋白排泄可作为氨基糖苷类药物相对结合亲和力的一个参数。
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