rad18 - 2在酿酒酵母中对几个表型特征的半显性。
Semidominance of rad18-2 for several phenotypic characters in Saccharomyces cerevisiae.
作者信息
Mayer V W, Goin C J
出版信息
Genetics. 1984 Apr;106(4):577-89. doi: 10.1093/genetics/106.4.577.
Abstract
Inbred diploid yeast strains heterozygous or homozygous for the rad18-2 allele and carrying markers for detection of mitotic recombination were constructed. The homozygous rad18-2/rad 18-2 strain was highly sensitive to killing by UV light, showed greatly elevated frequencies of spontaneous and induced mitotic recombination and was more sensitive to trimethoprim than the wild-type diploid. The heterozygous strain RAD18/rad 18-2 was intermediate in its response for these same phenotypic characters. These findings are discussed in the light of other studies in which incomplete dominance of genes involved in some aspect of DNA repair has been reported.
摘要
构建了对rad18 - 2等位基因杂合或纯合的近交二倍体酵母菌株，并带有用于检测有丝分裂重组的标记。纯合的rad18 - 2/rad 18 - 2菌株对紫外线杀伤高度敏感，自发和诱导的有丝分裂重组频率大幅升高，并且比野生型二倍体对甲氧苄啶更敏感。杂合菌株RAD18/rad 18 - 2在这些相同表型特征的反应上处于中间状态。根据其他报道了参与DNA修复某些方面的基因不完全显性的研究对这些发现进行了讨论。
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