Kline J, Stein Z A, Susser M, Warburton D
Am J Obstet Gynecol. 1978 Mar 15;130(6):708-11. doi: 10.1016/0002-9378(78)90333-2.
The hypothesis that the use of saccharin may increase the risk of spontaneous abortion was tested in a case-control study. Women who had had spontaneous abortions were compared with women who had been delivered after 28 weeks' gestation. Women with a history of diabetes were excluded from the analysis. The use of sugar substitutes during pregnancy was similar in cases and controls: 5.5 per cent of cases and 5.8 per cent of controls reported using sugar substitutes. The power of the analysis to detect a twofold increase in the frequency of use of sugar substitutes in cases as compared to controls was approximately 81 per cent. The analysis effectively controlled for all known potentially confounding variables: that is, age at last menstrual period, history of previous spontaneous abortions, smoking during pregnancy, and usual weight were controlled in the analysis.
在一项病例对照研究中，对使用糖精可能增加自然流产风险这一假设进行了检验。将发生自然流产的女性与妊娠28周后分娩的女性进行比较。分析中排除了有糖尿病病史的女性。病例组和对照组在孕期使用代糖的情况相似：5.5%的病例组和5.8%的对照组报告使用了代糖。该分析检测病例组代糖使用频率相较于对照组增加两倍的效能约为81%。该分析有效地控制了所有已知的潜在混杂变量：即末次月经时的年龄、既往自然流产史、孕期吸烟情况以及平时体重在分析中均得到了控制。
