Overall J E
J Clin Psychiatry. 1984 Apr;45(4 Pt 2):85-8.
Results from 11 independent double-blind placebo controlled studies of nomifensine were analyzed to assess the efficacy of the active drug vs. placebo in four depressive subtypes classified by Hamilton Depression Rating Scale profiles. Substantial nomifensine-placebo differences were seen in the anxious, suicidal, and vegetative subtypes; high rates of placebo response in the somatizing subtype resulted in nonsignificant treatment effects. Differing responses to antidepressant drugs based on phenomenologic subtypes of depression appear to merit further investigation.
对诺米芬辛11项独立双盲安慰剂对照研究的结果进行了分析，以评估活性药物与安慰剂在根据汉密尔顿抑郁量表剖面图分类的四种抑郁亚型中的疗效。在焦虑、自杀和植物神经亚型中，诺米芬辛与安慰剂之间存在显著差异；在躯体化亚型中，安慰剂反应率较高，导致治疗效果不显著。基于抑郁现象学亚型对抗抑郁药物的不同反应似乎值得进一步研究。
